In the CAF Confederation Cup, former champions Zamalek and USM Alger headline a compelling cast that includes Wydad, CR Belouizdad, Kaizer Chiefs, Stellenbosch, Azam, ZESCO Unitedand exciting debutants Nairobi United.
Opening night delivers immediate blockbusters as Pyramids welcome Rivers United in Cairo while RS Berkane face Power Dynamos in a North–South clash rich with subplots.
Heavyweights return with purpose as Al Ahly begin their hunt for a 13th crown against JS Kabylie, Espérance host Stade Malien, and Mamelodi Sundowns test their rhythm versus St Éloi Lupopo.
Regional narratives light up the Confederation Cup, where an Egyptian derby group springs into life with Zamalek hosting ZESCO United and Al Masry meeting Kaizer Chiefs.
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Fresh chapters are also written by debutants and rising forces, with Nairobi United travelling to Wydad, OC Safi visiting Djoliba, and Maniema Union hosting Azam in a tantalising East–Central Africa duel.
Two matchdays will be played before the start of the CAF Africa Cup of Nations Morocco 2025. The group phase will pause during the continental showpiece and resume in January 2026.
MATCHDAY 1 FIXTURES (All times GMT)
CAF Champions League
Friday, 21 November
13:00 — Al-Hilal Omdurman (SUD) vs MC Alger (ALG).
Saturday, 22 November
13:00 — Mamelodi Sundowns (RSA) vs St Éloi Lupopo (DRC)
13:00 — Young Africans (TAN) vs AS FAR Rabat (MAR)
16:00 — Al Ahly (EGY) vs JS Kabylie (ALG)
16:00 — Espérance Tunis (TUN) vs Stade Malien (MLI)
19:00 — RS Berkane (MAR) vs Power Dynamos (ZAM)
19:00 — Pyramids (EGY) vs Rivers United (NGA).
Sunday, 23 November
13:00 — Simba (TAN) vs Petro Atlético (ANG).
CAF Confederation Cup
Saturday, 22 November
19:00 — CR Belouizdad (ALG) vs Singida Black Stars (TAN).
Sunday, 23 November
13:00 — Maniema (DRC) vs Azam (TAN)
13:00 — Stellenbosch (RSA) vs AS Otoho (CON)
16:00 — Al Masry (EGY) vs Kaizer Chiefs (RSA)
16:00 — Djoliba (MLI) vs OC Safi (MAR)
19:00 — USM Alger (ALG) vs San Pedro (CIV)
19:00 — Wydad (MAR) vs Nairobi United (KEN)
19:00 — Zamalek (EGY) vs ZESCO United (ZAM).
CAF.